Clonal competition within complex evolutionary hierarchies shapes AML over time
Clonal evolution and heterogeneity has strong implications for treatment response in acute myeloid leukemia. Here, the authors use patient derived in vivo modelling to highlight the complex clonal and evolutionary dynamics underpinning acute myeloid leukemia progression.
Main Authors: | , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2020-02-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-14106-0 |