E3 ligase MG53 suppresses tumor growth by degrading cyclin D1

E3 ligase MG53 suppresses tumor growth by degrading cyclin D1

Abstract Due to the essential role of cyclin D1 in regulating transition from G1 to S phase in cell cycle, aberrant cyclin D1 expression is a major oncogenic event in many types of cancers. In particular, the dysregulation of ubiquitination-dependent degradation of cyclin D1 contributes to not only...

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Bibliographic Details
Main Authors: Meng Fang, Hong-Kun Wu, Yumeng Pei, Yan Zhang, Xiangyu Gao, Yanyun He, Gengjia Chen, Fengxiang Lv, Peng Jiang, Yumei Li, Wenwen Li, Lin Wang, Jiafu Ji, Xinli Hu, Rui-Ping Xiao
Format: Article
Language:English
Published: Nature Publishing Group 2023-07-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-023-01458-9

Internet

https://doi.org/10.1038/s41392-023-01458-9

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