HMGB1 cleavage by complement C1s and its potent anti-inflammatory product

HMGB1 cleavage by complement C1s and its potent anti-inflammatory product

Complement C1s association with the pathogenesis of several diseases cannot be simply explained only by considering its main role in activating the classical complement pathway. This suggests that non-canonical functions are to be deciphered for this protease. Here the focus is on C1s cleavage of HM...

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Bibliographic Details
Main Authors: Marie Lorvellec, Anne Chouquet, Jonas Koch, Isabelle Bally, Luca Signor, Jeanne Vigne, Fabien Dalonneau, Nicole M. Thielens, Thierry Rabilloud, Bastien Dalzon, Véronique Rossi, Christine Gaboriaud
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
complement system
HMGB1 alarmin
cytokines
C1 protease
RAW264.7 cells
macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1151731/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1151731/full

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