RNAi Screening Uncovers a Synthetic Sick Interaction between CtIP and the BARD1 Tumor Suppressor

RNAi Screening Uncovers a Synthetic Sick Interaction between CtIP and the BARD1 Tumor Suppressor

Human CtIP is best known for its role in DNA end resection to initiate DNA double-strand break repair by homologous recombination. Recently, CtIP has also been shown to protect reversed replication forks from nucleolytic degradation upon DNA replication stress. However, still little is known about t...

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Bibliographic Details
Main Authors: Hella A. Bolck, Sara Przetocka, Roger Meier, Christine von Aesch, Christina Zurfluh, Kay Hänggi, Vincent Spegg, Matthias Altmeyer, Michael Stebler, Simon F. Nørrelykke, Peter Horvath, Alessandro A. Sartori, Antonio Porro
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cells
Subjects:
CtIP
BARD1
BRCA1
synthetic lethality
replication stress
DNA damage
Online Access:https://www.mdpi.com/2073-4409/11/4/643

Internet

https://www.mdpi.com/2073-4409/11/4/643

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