Impact of secondary TCR engagement on the heterogeneity of pathogen-specific CD8+ T cell response during acute and chronic toxoplasmosis.

Impact of secondary TCR engagement on the heterogeneity of pathogen-specific CD8+ T cell response during acute and chronic toxoplasmosis.

Initial TCR engagement (priming) of naive CD8+ T cells results in T cell expansion, and these early events influence the generation of diverse effector and memory populations. During infection, activated T cells can re-encounter cognate antigen, but how these events influence local effector response...

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Bibliographic Details
Main Authors: Lindsey A Shallberg, Anthony T Phan, David A Christian, Joseph A Perry, Breanne E Haskins, Daniel P Beiting, Tajie H Harris, Anita A Koshy, Christopher A Hunter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010296

Internet

https://doi.org/10.1371/journal.ppat.1010296

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