Inclusion of variants discovered from diverse populations improves polygenic risk score transferability

Inclusion of variants discovered from diverse populations improves polygenic risk score transferability

Summary: The majority of polygenic risk scores (PRSs) have been developed and optimized in individuals of European ancestry and may have limited generalizability across other ancestral populations. Understanding aspects of PRSs that contribute to this issue and determining solutions is complicated b...

Full description

Bibliographic Details
Main Authors: Taylor B. Cavazos, John S. Witte
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:HGG Advances
Subjects:
polygenic risk scores
population genetics
statistical genetics
local ancestry
GWAS
Online Access:http://www.sciencedirect.com/science/article/pii/S2666247720300178

Internet

http://www.sciencedirect.com/science/article/pii/S2666247720300178

Similar Items