Combination of NF-kB targeted siRNA and methotrexate in a hybrid nanocarrier towards the effective treatment in rheumatoid arthritis

Combination of NF-kB targeted siRNA and methotrexate in a hybrid nanocarrier towards the effective treatment in rheumatoid arthritis

Abstract Background The transcription factor NF-kB plays an important role in the pathogenesis of rheumatoid arthritis (RA). Effective treatment of RA is hindered due to the lack of specificity of small molecules in the inflamed joints. In this study, we aimed to develop a unique hybrid-nanoparticle...

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Bibliographic Details
Main Authors: Weifeng Duan, Huan Li
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Journal of Nanobiotechnology
Subjects:
Rheumatoid arthritis
Methotrexate
siRNA
Liposome
Calcium phosphate
Inflammation
Online Access:http://link.springer.com/article/10.1186/s12951-018-0382-x

Internet

http://link.springer.com/article/10.1186/s12951-018-0382-x

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