The Hepatitis C Virus-Induced Membranous Web and Associated Nuclear Transport Machinery Limit Access of Pattern Recognition Receptors to Viral Replication Sites.

The Hepatitis C Virus-Induced Membranous Web and Associated Nuclear Transport Machinery Limit Access of Pattern Recognition Receptors to Viral Replication Sites.

Hepatitis C virus (HCV) is a positive-strand RNA virus of the Flaviviridae family and a major cause of liver disease worldwide. HCV replicates in the cytoplasm, and the synthesis of viral proteins induces extensive rearrangements of host cell membranes producing structures, collectively termed the m...

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Bibliographic Details
Main Authors: Christopher J Neufeldt, Michael A Joyce, Nicholas Van Buuren, Aviad Levin, Karla Kirkegaard, Michael Gale, D Lorne J Tyrrell, Richard W Wozniak
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1005428

Internet

https://doi.org/10.1371/journal.ppat.1005428

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