TP53 gain-of-function mutation modulates the immunosuppressive microenvironment in non-HPV-associated oral squamous cell carcinoma

TP53 gain-of-function mutation modulates the immunosuppressive microenvironment in non-HPV-associated oral squamous cell carcinoma

Background TP53, the most mutated gene in solid cancers, has a profound impact on most hallmarks of cancer. Somatic TP53 mutations occur in high frequencies in head and neck cancers, including oral squamous cell carcinoma (OSCC). Our study aims to understand the role of TP53 gain-of-function mutatio...

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Bibliographic Details
Main Authors: Bo Yuan, Xi Chen, Wenyi Wang, Ratna Veeramachaneni, Andrew G Sikora, Yewen Shi, Xiaoyong Ren, Shaolong Cao, Fabio Henrique Brasil da Costa, Alanis E Rodriguez Rosario, Arnoldo Corona, Chieko Michikawa, Abdullah A Osman, Tongxin Xie, Jeffrey N Myers, Roberto Rangel
Format: Article
Language:English
Published: BMJ Publishing Group 2023-08-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/11/8/e006666.full

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https://jitc.bmj.com/content/11/8/e006666.full

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