Multiomics analysis identifies oxidative phosphorylation as a cancer vulnerability arising from myristoylation inhibition

Multiomics analysis identifies oxidative phosphorylation as a cancer vulnerability arising from myristoylation inhibition

Abstract Background In humans, two ubiquitously expressed N-myristoyltransferases, NMT1 and NMT2, catalyze myristate transfer to proteins to facilitate membrane targeting and signaling. We investigated the expression of NMTs in numerous cancers and found that NMT2 levels are dysregulated by epigenet...

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Bibliographic Details
Main Authors: Erwan Beauchamp, Jay M. Gamma, Christopher R. Cromwell, Eman W. Moussa, Rony Pain, Morris A. Kostiuk, Claudia Acevedo-Morantes, Aishwarya Iyer, Megan Yap, Krista M. Vincent, Lynne M. Postovit, Olivier Julien, Basil P. Hubbard, John R. Mackey, Luc G. Berthiaume
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Journal of Translational Medicine
Subjects:
N-myristoylation
N-myristoyltransferase
NMT inhibitor (NMTI)
PCLX-001 (zelenirstat)
Cancer
Complex I
Online Access:https://doi.org/10.1186/s12967-024-05150-6

Internet

https://doi.org/10.1186/s12967-024-05150-6

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