MC38 colorectal tumor cell lines from two different sources display substantial differences in transcriptome, mutanome and neoantigen expression

MC38 colorectal tumor cell lines from two different sources display substantial differences in transcriptome, mutanome and neoantigen expression

IntroductionThe cell line MC38 is a commonly used murine model for colorectal carcinoma. It has a high mutational burden, is sensitive to immune checkpoint immunotherapy and endogenous CD8+ T cell responses against neoantigens have been reported.MethodsHere, we re-sequenced exomes and transcriptomes...

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Bibliographic Details
Main Authors: Barbara Schrörs, Brett J. Hos, Ikra G. Yildiz, Martin Löwer, Franziska Lang, Christoph Holtsträter, Julia Becker, Mathias Vormehr, Ugur Sahin, Ferry Ossendorp, Mustafa Diken
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
MC38
colorectal carcinoma
mutation analysis
neoantigens
expression profile
murine tumor model
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1102282/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1102282/full

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