Novel Toscana Virus Reverse Genetics System Establishes NSs as an Antagonist of Type I Interferon Responses

Novel Toscana Virus Reverse Genetics System Establishes NSs as an Antagonist of Type I Interferon Responses

The sand fly-borne Toscana virus (TOSV) is the major cause of human meningoencephalitis in the Mediterranean basin during the summer season. In this work, we have developed a T7 RNA polymerase-driven reverse genetics system to recover infectious particles of a lineage B strain of TOSV. The viral pro...

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Bibliographic Details
Main Authors: Franziska Woelfl, Psylvia Léger, Nadia Oreshkova, Felix Pahmeier, Stefan Windhaber, Jana Koch, Megan Stanifer, Gleyder Roman Sosa, Zina M. Uckeley, Felix A. Rey, Steeve Boulant, Jeroen Kortekaas, Paul J. Wichgers Schreur, Pierre-Yves Lozach
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Viruses
Subjects:
Arbovirus
<i>Bunyavirales</i>
interferon
neglected diseases
<i>Phenuiviridae</i>
<i>Phlebovirus</i>
Online Access:https://www.mdpi.com/1999-4915/12/4/400

Internet

https://www.mdpi.com/1999-4915/12/4/400

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