MiR-30 promotes fatty acid beta-oxidation and endothelial cell dysfunction and is a circulating biomarker of coronary microvascular dysfunction in pre-clinical models of diabetes

MiR-30 promotes fatty acid beta-oxidation and endothelial cell dysfunction and is a circulating biomarker of coronary microvascular dysfunction in pre-clinical models of diabetes

Abstract Background Type 2 diabetes (T2D) is associated with coronary microvascular dysfunction, which is thought to contribute to compromised diastolic function, ultimately culminating in heart failure with preserved ejection fraction (HFpEF). The molecular mechanisms remain incompletely understood...

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Main Authors: Shawn Veitch, Makon-Sébastien Njock, Mark Chandy, M. Ahsan Siraj, Lijun Chi, HaoQi Mak, Kai Yu, Kumaragurubaran Rathnakumar, Carmina Anjelica Perez-Romero, Zhiqi Chen, Faisal J. Alibhai, Dakota Gustafson, Sneha Raju, Ruilin Wu, Dorrin Zarrin Khat, Yaxu Wang, Amalia Caballero, Patrick Meagher, Edward Lau, Lejla Pepic, Henry S. Cheng, Natalie J. Galant, Kathryn L. Howe, Ren-Ke Li, Kim A. Connelly, Mansoor Husain, Paul Delgado-Olguin, Jason E. Fish
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Cardiovascular Diabetology
Subjects:
Endothelial cell
Microvasculature
Diabetes
Extracellular vesicle
microRNA
Biomarker
Online Access:https://doi.org/10.1186/s12933-022-01458-z

Internet

https://doi.org/10.1186/s12933-022-01458-z

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