The Use of a Non-Conventional Long-Lived Gallium Radioisotope <sup>66</sup>Ga Improves Imaging Contrast of EGFR Expression in Malignant Tumours Using DFO-ZEGFR:2377 Affibody Molecule

The Use of a Non-Conventional Long-Lived Gallium Radioisotope <sup>66</sup>Ga Improves Imaging Contrast of EGFR Expression in Malignant Tumours Using DFO-ZEGFR:2377 Affibody Molecule

Epidermal growth factor receptor (EGFR) is overexpressed in many malignancies. EGFR-targeted therapy extends survival of patients with disseminated cancers. Radionuclide molecular imaging of EGFR expression would make EGFR-directed treatment more personalized and therefore more efficient. A previous...

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Bibliographic Details
Main Authors: Maryam Oroujeni, Tianqi Xu, Katherine Gagnon, Sara S. Rinne, Jan Weis, Javad Garousi, Ken G. Andersson, John Löfblom, Anna Orlova, Vladimir Tolmachev
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Pharmaceutics
Subjects:
epidermal growth factor receptor
affibody molecule
PET imaging
gallium-66
ZEGFR:2377
A431 xenograft
Online Access:https://www.mdpi.com/1999-4923/13/2/292

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https://www.mdpi.com/1999-4923/13/2/292

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