Cerebral Aβ deposition in an Aβ-precursor protein-transgenic rhesus monkey

Cerebral Aβ deposition in an Aβ-precursor protein-transgenic rhesus monkey

With the ultimate goal of developing a more representative animal model of Alzheimer's disease (AD), two female amyloid-β-(Aβ) precursor protein-transgenic (APPtg) rhesus monkeys were generated by lentiviral transduction of the APP gene into rhesus oocytes, followed by in vitro fertilization an...

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Bibliographic Details
Main Authors: Anthony W.S. Chan, In Ki Cho, Chun-Xia Li, Xiaodong Zhang, Sudeep Patel, Rebecca Rusnak, Jessica Raper, Jocelyne Bachevalier, Sean P. Moran, Tim Chi, Katherine H. Cannon, Carissa E. Hunter, Ryan C. Martin, Hailian Xiao, Shang-Hsun Yang, Sanjeev Gumber, James G. Herndon, Rebecca F. Rosen, William T. Hu, James J. Lah, Allan I. Levey, Yoland Smith, Lary C. Walker
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Aging Brain
Subjects:
Alzheimer's disease
Amyloid precursor protein
Animal model
Cerebral amyloid angiopathy
Tau
Online Access:http://www.sciencedirect.com/science/article/pii/S2589958922000160

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http://www.sciencedirect.com/science/article/pii/S2589958922000160

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