Identification of residues critical for the extension of Munc18-1 domain 3a

Identification of residues critical for the extension of Munc18-1 domain 3a

Abstract Background Neurotransmitter release depends on the fusion of synaptic vesicles with the presynaptic membrane and is mainly mediated by SNARE complex assembly. During the transition of Munc18-1/Syntaxin-1 to the SNARE complex, the opening of the Syntaxin-1 linker region catalyzed by Munc13-1...

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Bibliographic Details
Main Authors: Xianping Wang, Jihong Gong, Le Zhu, Huidan Chen, Ziqi Jin, Xiaoqiang Mo, Shen Wang, Xiaofei Yang, Cong Ma
Format: Article
Language:English
Published: BMC 2023-07-01
Series:BMC Biology
Subjects:
Munc18-1
Syntaxin-1
Munc13-1
SNARE complex
Conformational change
Synaptic exocytosis
Online Access:https://doi.org/10.1186/s12915-023-01655-6

Internet

https://doi.org/10.1186/s12915-023-01655-6

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