Loss of TET2 increases B-1 cell number and IgM production while limiting CDR3 diversity

Loss of TET2 increases B-1 cell number and IgM production while limiting CDR3 diversity

Recent studies have demonstrated a role for Ten-Eleven Translocation-2 (TET2), an epigenetic modulator, in regulating germinal center formation and plasma cell differentiation in B-2 cells, yet the role of TET2 in regulating B-1 cells is largely unknown. Here, B-1 cell subset numbers, IgM production...

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Bibliographic Details
Main Authors: Emily Dennis, Maria Murach, Cassidy M.R. Blackburn, Melissa Marshall, Katherine Root, Tanyaporn Pattarabanjird, Justine Deroissart, Loren D. Erickson, Christoph J. Binder, Stefan Bekiranov, Coleen A. McNamara
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
innate B cells
B-1 cells
ten-eleven translocation-2 (TET2)
natural antibodies (Nab)
immunoglobulin M (IgM)
B cell receptor (BCR)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1380641/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1380641/full

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