Structural effects of inosine substitution in telomeric DNA quadruplex

Structural effects of inosine substitution in telomeric DNA quadruplex

The telomeric DNA, a distal region of eukaryotic chromosome containing guanine-rich repetitive sequence of (TTAGGG)n, has been shown to adopt higher-order structures, specifically G-quadruplexes (G4s). Previous studies have demonstrated the implication of G4 in tumor inhibition through chromosome ma...

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Bibliographic Details
Main Authors: Ya Ying Zheng, Ricky Dartawan, Yuhan Wu, Chengze Wu, Hope Zhang, Jeanne Lu, Ashley Hu, Sweta Vangaveti, Jia Sheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Chemistry
Subjects:
G-quadruplex
telomeric repeats
inosine
G-I mutation
CD spectra
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2024.1330378/full

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https://www.frontiersin.org/articles/10.3389/fchem.2024.1330378/full

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