Vitamin D, FOXO3a, and Sirtuin1 in Hashimoto's Thyroiditis and Differentiated Thyroid Cancer

Vitamin D, FOXO3a, and Sirtuin1 in Hashimoto's Thyroiditis and Differentiated Thyroid Cancer

Background: Protective effects of vitamin D have been reported in autoimmune and malignant thyroid diseases, though little is known about the underlying mechanism. Sirtuin 1 histon deacethylase (SIRT1) links the vitamin D pathway with regulation of transcription factor FOXO3a, a key player in cell c...

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Bibliographic Details
Main Authors: Natascha Roehlen, Claudia Doering, Martin-Leo Hansmann, Frank Gruenwald, Christian Vorlaender, Wolf Otto Bechstein, Katharina Holzer, Klaus Badenhoop, Marissa Penna-Martinez
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Endocrinology
Subjects:
sirtuin1
FOXO3a
vitamin D
vitamin D receptor
differentiated thyroid carcinoma
Hashimoto's thyroiditis
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00527/full

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https://www.frontiersin.org/article/10.3389/fendo.2018.00527/full

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