A patient-derived mutation of epilepsy-linked LGI1 increases seizure susceptibility through regulating Kv1.1

A patient-derived mutation of epilepsy-linked LGI1 increases seizure susceptibility through regulating Kv1.1

Abstract Background Autosomal dominant lateral temporal epilepsy (ADLTE) is an inherited syndrome caused by mutations in the leucine-rich glioma inactivated 1 (LGI1) gene. It is known that functional LGI1 is secreted by excitatory neurons, GABAergic interneurons, and astrocytes, and regulates AMPA-t...

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Main Authors: Lin Zhou, Kang Wang, Yuxiang Xu, Bin-Bin Dong, Deng-Chang Wu, Zhao-Xiang Wang, Xin-Tai Wang, Xin-Yu Cai, Jin-Tao Yang, Rui Zheng, Wei Chen, Ying Shen, Jian-She Wei
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Cell & Bioscience
Subjects:
ADLTE
Epilepsy
Leucine-rich glioma inactivated 1
Precision medicine
Online Access:https://doi.org/10.1186/s13578-023-00983-y

Internet

https://doi.org/10.1186/s13578-023-00983-y

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