Exploration of the mechanism of NORAD activation of TGF-β1/Smad3 through miR-136-5p and promotion of tacrolimus-induced renal fibrosis

Exploration of the mechanism of NORAD activation of TGF-β1/Smad3 through miR-136-5p and promotion of tacrolimus-induced renal fibrosis

AbstractBackground Tacrolimus is a potent immunosuppressant, but has various side effects, with nephrotoxicity being the most common. Renal fibrosis is an important process of tacrolimus nephrotoxicity. Therefore, it is important to identify the factors that contribute to renal fibrosis after tacrol...

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Bibliographic Details
Main Authors: Lei Liu, Jia Guo, Xin-lu Pang, Wen-jun Shang, Zhi-gang Wang, Jun-xiang Wang, Xian-lei Yang, Gui-wen Feng
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Renal Failure
Subjects:
Tacrolimus
renal fibrosis
NORAD
miR-136-5p
TGF-β1/Smad3
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2022.2147083

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https://www.tandfonline.com/doi/10.1080/0886022X.2022.2147083

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