Co-receptor CD8-mediated modulation of T-cell receptor functional sensitivityand epitope recognition degeneracy

Co-receptor CD8-mediated modulation of T-cell receptor functional sensitivityand epitope recognition degeneracy

The interaction between T-cell receptors (TCRs) and peptideepitopes is highly degenerate: a TCR iscapable of interacting productively with a wide range of differentpeptide ligands, involving not only crossreactivity proper(similar epitopes elicit strong responses), but alsopolyspecificity (ligands w...

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Bibliographic Details
Main Authors: Barbara eSzomolay, Tamsin eWlliams, Linda eWooldridge, Hugo Antonius Van Den Berg
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-10-01
Series:Frontiers in Immunology
Subjects:
Mathematics
degeneracy
T-cell receptor
coreceptor CD8
functional sensitivity
ligand focussing
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00329/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00329/full

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