Increased Frequency of CD4<sup>+</sup> Follicular Helper T and CD8<sup>+</sup> Follicular T Cells in Human Lymph Node Biopsies during the Earliest Stages of Rheumatoid Arthritis

Increased Frequency of CD4<sup>+</sup> Follicular Helper T and CD8<sup>+</sup> Follicular T Cells in Human Lymph Node Biopsies during the Earliest Stages of Rheumatoid Arthritis

Follicular T helper cells (Tfh cells) provide key B-cell help and are essential in germinal center formation and (auto) antibody generation. To gain more insight into their role during the earliest phase of rheumatoid arthritis (RA), we analyzed their frequencies, phenotypes, and cytokine profiles i...

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Bibliographic Details
Main Authors: Dornatien Chuo Anang, Tamara H. Ramwadhdoebe, Janine S. Hähnlein, Bo van Kuijk, Noortje Smits, Krijn P. van Lienden, Mario Maas, Daniëlle M. Gerlag, Paul P. Tak, Niek de Vries, Lisa G. M. van Baarsen
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
rheumatoid arthritis
lymph nodes
T lymphocytes
B lymphocytes
follicular T helper cells
Online Access:https://www.mdpi.com/2073-4409/11/7/1104

Internet

https://www.mdpi.com/2073-4409/11/7/1104

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