Suppression of Superficial Microglial Activation by Spinal Cord Stimulation Attenuates Neuropathic Pain Following Sciatic Nerve Injury in Rats

Suppression of Superficial Microglial Activation by Spinal Cord Stimulation Attenuates Neuropathic Pain Following Sciatic Nerve Injury in Rats

We evaluated the mechanisms underlying the spinal cord stimulation (SCS)-induced analgesic effect on neuropathic pain following spared nerve injury (SNI). On day 3 after SNI, SCS was performed for 6 h by using electrodes paraspinally placed on the L4-S1 spinal cord. The effects of SCS and intraperit...

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Bibliographic Details
Main Authors: Masamichi Shinoda, Satoshi Fujita, Shiori Sugawara, Sayaka Asano, Ryo Koyama, Shintaro Fujiwara, Kumi Soma, Takaaki Tamagawa, Tomoyuki Matsui, Daisuke Ikutame, Masatoshi Ando, Ayaka Osada, Yuki Kimura, Kazutaka Kobayashi, Takamitsu Yamamoto, Kuniko Kusama-Eguchi, Masayuki Kobayashi, Yoshinori Hayashi, Koichi Iwata
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
spinal cord stimulation
spared nerve injury
microglial activation
somatosensory cortex
in vivo optical imaging
Online Access:https://www.mdpi.com/1422-0067/21/7/2390

Internet

https://www.mdpi.com/1422-0067/21/7/2390

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