Caspase 3‐specific cleavage of MEK1 suppresses ERK signaling and sensitizes cells to stress‐induced apoptosis

Proper regulation of apoptotic cell death is crucial for normal development and homeostasis in multicellular organisms and is achieved by the balance between pro‐apoptotic processes, such as caspase activation, and pro‐survival signaling, such as extracellular signal‐regulated kinase (ERK) activatio...

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Bibliographic Details
Main Authors: Hisashi Moriizumi, Yuji Kubota, Tomoyuki Tsuchiya, Ryosuke Naka, Mutsuhiro Takekawa
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:FEBS Open Bio
Subjects:
Online Access:https://doi.org/10.1002/2211-5463.13574