Alzheimer's amyloid‐β and tau protein accumulation is associated with decreased expression of the LDL receptor‐associated protein in human brain tissue

Abstract Introduction One of the major neuropathological features of Alzheimer's disease (AD) is the accumulation of amyloid‐β (Aβ) protein in the brain. Evidence suggests that the low‐density lipoprotein receptor‐associated protein (RAP) binds strongly to Aβ and enhances its cellular uptake an...

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Bibliographic Details
Main Authors: Claire E. Shepherd, Andrew J. Affleck, Anita Y. Bahar, Francine Carew‐Jones, Gillian Gregory, David H. Small, Glenda M. Halliday
Format: Article
Language:English
Published: Wiley 2020-07-01
Series:Brain and Behavior
Subjects:
Online Access:https://doi.org/10.1002/brb3.1672