The Phr1 Ubiquitin Ligase Promotes Injury-Induced Axon Self-Destruction

Axon degeneration is an evolutionarily conserved process that drives the loss of damaged axons and is an early event in many neurological disorders, so it is important to identify the molecular constituents of this poorly understood mechanism. Here, we demonstrate that the Phr1 E3 ubiquitin ligase i...

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Bibliographic Details
Main Authors: Elisabetta Babetto, Bogdan Beirowski, Emilie V. Russler, Jeffrey Milbrandt, Aaron DiAntonio
Format: Article
Language:English
Published: Elsevier 2013-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713001800