A Bayesian non-inferiority approach using experts’ margin elicitation – application to the monitoring of safety events

A Bayesian non-inferiority approach using experts’ margin elicitation – application to the monitoring of safety events

Abstract Background When conducing Phase-III trial, regulatory agencies and investigators might want to get reliable information about rare but serious safety outcomes during the trial. Bayesian non-inferiority approaches have been developed, but commonly utilize historical placebo-controlled data t...

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Bibliographic Details
Main Authors: Camille Aupiais, Corinne Alberti, Thomas Schmitz, Olivier Baud, Moreno Ursino, Sarah Zohar
Format: Article
Language:English
Published: BMC 2019-09-01
Series:BMC Medical Research Methodology
Subjects:
Clinical trial
Non-inferiority
Bayesian inference
Mixture model
Children
Elicitation
Online Access:http://link.springer.com/article/10.1186/s12874-019-0826-5

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http://link.springer.com/article/10.1186/s12874-019-0826-5

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