Amyloid-Beta Peptides and Activated Astroglia Impairs Proliferation of Nerve Growth Factor Releasing Cells In Vitro: Implication for Encapsulated Cell Biodelivery-Mediated AD Therapy

Amyloid-Beta Peptides and Activated Astroglia Impairs Proliferation of Nerve Growth Factor Releasing Cells In Vitro: Implication for Encapsulated Cell Biodelivery-Mediated AD Therapy

Alzheimer’s disease (AD) treatment is constrained due to the inability of peripherally administered therapeutic molecules to cross the blood–brain barrier. Encapsulated cell biodelivery (ECB) devices, a tissue-targeted approach for local drug release, was previously optimized for human mature nerve...

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Bibliographic Details
Main Authors: Sumonto Mitra, Silvia Turchetto, Winant Van Os, Lars U. Wahlberg, Bengt Linderoth, Homira Behbahani, Maria Eriksdotter
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
Alzheimer’s disease (AD)
astrocytes
amyloid beta (Aβ)
encapsulated cell biodelivery (ECB)
nerve growth factor (NGF)
drug delivery strategy optimization
Online Access:https://www.mdpi.com/2073-4409/10/11/2834

Internet

https://www.mdpi.com/2073-4409/10/11/2834

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