Be Aggressive! Amorphous Excipients Enabling Single-Step Freeze-Drying of Monoclonal Antibody Formulations

Be Aggressive! Amorphous Excipients Enabling Single-Step Freeze-Drying of Monoclonal Antibody Formulations

Short freeze-drying cycles for biopharmaceuticals are desirable. Formulations containing an amorphous disaccharide, such as sucrose, are prone to collapse upon aggressive primary drying at higher shelf temperature. We used 2-hydroxypropyl-betacyclodextrin (HPBCD) in combination with sucrose and poly...

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Bibliographic Details
Main Authors: Christina Haeuser, Pierre Goldbach, Joerg Huwyler, Wolfgang Friess, Andrea Allmendinger
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Pharmaceutics
Subjects:
glass transition
collapse
freeze-drying
cyclodextrin
antibody
cycle optimization
single-step freeze-drying
Online Access:https://www.mdpi.com/1999-4923/11/11/616

Internet

https://www.mdpi.com/1999-4923/11/11/616

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