Epithelial SIRT6 governs IL-17A pathogenicity and drives allergic airway inflammation and remodeling

Epithelial SIRT6 governs IL-17A pathogenicity and drives allergic airway inflammation and remodeling

Abstract Dysregulation of IL-17A is closely associated with airway inflammation and remodeling in severe asthma. However, the molecular mechanisms by which IL-17A is regulated remain unclear. Here we identify epithelial sirtuin 6 (SIRT6) as an epigenetic regulator that governs IL-17A pathogenicity i...

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Bibliographic Details
Main Authors: Jingyun Quan, Xiaoxia Wen, Guomei Su, Yu Zhong, Tong Huang, Zhilin Xiong, Jiewen Huang, Yingying Lv, Shihai Li, Shuhua Luo, Chaole Luo, Xin Cai, Xianwen Lai, Yuanyuan Xiang, Song Guo Zheng, Yiming Shao, Haitao Lin, Xiao Gao, Jing Tang, Tianwen Lai
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-44179-x

Internet

https://doi.org/10.1038/s41467-023-44179-x

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