Epithelial SIRT6 governs IL-17A pathogenicity and drives allergic airway inflammation and remodeling

Epithelial SIRT6 governs IL-17A pathogenicity and drives allergic airway inflammation and remodeling

Abstract Dysregulation of IL-17A is closely associated with airway inflammation and remodeling in severe asthma. However, the molecular mechanisms by which IL-17A is regulated remain unclear. Here we identify epithelial sirtuin 6 (SIRT6) as an epigenetic regulator that governs IL-17A pathogenicity i...

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書目詳細資料
Main Authors: Jingyun Quan, Xiaoxia Wen, Guomei Su, Yu Zhong, Tong Huang, Zhilin Xiong, Jiewen Huang, Yingying Lv, Shihai Li, Shuhua Luo, Chaole Luo, Xin Cai, Xianwen Lai, Yuanyuan Xiang, Song Guo Zheng, Yiming Shao, Haitao Lin, Xiao Gao, Jing Tang, Tianwen Lai
格式: Article
語言:English
出版: Nature Portfolio 2023-12-01
叢編:Nature Communications
在線閱讀:https://doi.org/10.1038/s41467-023-44179-x

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https://doi.org/10.1038/s41467-023-44179-x

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