GPR Expression in Intestinal Biopsies From SCT Patients Is Upregulated in GvHD and Is Suppressed by Broad-Spectrum Antibiotics

GPR Expression in Intestinal Biopsies From SCT Patients Is Upregulated in GvHD and Is Suppressed by Broad-Spectrum Antibiotics

Microbiota can exert immunomodulatory effects by short-chain fatty acids (SCFA) in experimental models of graft-versus-host disease (GvHD) after allogeneic hematopoietic stem cell transplantation (allo-SCT). Therefore we aimed to analyze the expression of SCFAs sensing G-protein coupled receptor GPR...

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Bibliographic Details
Main Authors: Sakhila Ghimire, Daniela Weber, Katrin Hippe, Elisabeth Meedt, Matthias Hoepting, Anna-Sophia Kattner, Andreas Hiergeist, André Gessner, Carina Matos, Saroj Ghimire, Daniel Wolff, Matthias Edinger, Petra Hoffmann, Hendrik Poeck, Wolfgang Herr, Ernst Holler
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
broad-spectrum antibiotics
GPR
Foxp3
GvHD
microbiota
SCFA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.753287/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.753287/full

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