Preclinical assessment of a novel human antibody VH domain targeting mesothelin as an antibody-drug conjugate

Preclinical assessment of a novel human antibody VH domain targeting mesothelin as an antibody-drug conjugate

Mesothelin (MSLN) has been a validated tumor-associated antigen target for several solid tumors for over a decade, making it an attractive option for therapeutic interventions. Novel antibodies with high affinity and better therapeutic properties are needed. In the current study, we have isolated an...

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Bibliographic Details
Main Authors: Zehua Sun, Xiaojie Chu, Cynthia Adams, Tatiana V. Ilina, Michel Guerrero, Guowu Lin, Chuan Chen, Dontcho Jelev, Rieko Ishima, Wei Li, John W. Mellors, Guillermo Calero, Dimiter S. Dimitrov
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Molecular Therapy: Oncolytics
Subjects:
VH domain
library
ADC
MSLN
in vivo distribution
structure
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770523000694

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http://www.sciencedirect.com/science/article/pii/S2372770523000694

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