Polygenic risk for triglyceride levels in the presence of a high impact rare variant

Polygenic risk for triglyceride levels in the presence of a high impact rare variant

Abstract Background Elevated triglyceride (TG) levels are a heritable and modifiable risk factor for cardiovascular disease and have well-established associations with common genetic variation captured in a polygenic risk score (PRS). In young adulthood, the 22q11.2 microdeletion conveys a 2-fold in...

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Bibliographic Details
Main Authors: Shengjie Ying, Tracy Heung, Bhooma Thiruvahindrapuram, Worrawat Engchuan, Yue Yin, Christina Blagojevic, Zhaolei Zhang, Robert A. Hegele, Ryan K. C. Yuen, Anne S. Bassett
Format: Article
Language:English
Published: BMC 2023-11-01
Series:BMC Medical Genomics
Subjects:
Triglyceride
Lipid
Polygenic risk score
22q11.2 microdeletion
Genome sequencing
Online Access:https://doi.org/10.1186/s12920-023-01717-2

Internet

https://doi.org/10.1186/s12920-023-01717-2

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