Analytical quality-by-design approach for development and validation of HPLC method for the simultaneous estimation of omarigliptin, metformin, and ezetimibe: application to human plasma and dosage forms

Abstract A simple, selective, and sensitive RP-HPLC method was proposed for the simultaneous determination of two co-administered antidiabetic drugs (omarigliptin and metformin) with an anti-hyperlipidemic drug (ezetimibe) in a medicinally-recommended ratio of 2.5:50:1, respectively. The proposed pr...

Full description

Bibliographic Details
Main Authors: Galal Magdy, Amira A. Al-enna, Fathalla Belal, Ramadan A. El-Domany, Ahmed M. Abdel-Megied
Format: Article
Language:English
Published: BMC 2023-05-01
Series:BMC Chemistry
Subjects:
Online Access:https://doi.org/10.1186/s13065-023-00955-w