Upregulation of PARG in prostate cancer cells suppresses their malignant behavior and downregulates tumor-promoting genes

Upregulation of PARG in prostate cancer cells suppresses their malignant behavior and downregulates tumor-promoting genes

Post-translational modification of nuclear proteins through the addition of poly(ADP-ribose) (pADPr) moieties is upregulated in many metastatic cancers, where the high levels of pADPr have often been associated with poor cancer prognosis. Although the inhibitors of poly(ADP-ribose) polymerases (PARP...

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Bibliographic Details
Main Authors: Yaroslava Karpova, Sarah J. Johnson, Guillaume Bordet, Danping Guo, Atreyi Ghatak, Dmitriy A. Markov, Alexei V. Tulin
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Prostate cancer
PC-3
PARG
PADPr
Chemokines
PARP
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222008939

Internet

http://www.sciencedirect.com/science/article/pii/S0753332222008939

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