Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer’s disease therapy

Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer’s disease therapy

In view of the multifactorial nature of Alzheimer’s disease (AD), multitarget small molecules (MTSM) represent the most potent and attractive therapeutic strategy to design new drugs for Alzheimer’s disease therapy. The new MTSM KojoTacrines (KTs) were designed and synthesized by juxtaposition of se...

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Bibliographic Details
Main Authors: Youssef Dgachi, Hélène Martin, Rim Malek, Daniel Jun, Jana Janockova, Vendula Sepsova, Ondrej Soukup, Isabel Iriepa, Ignacio Moraleda, Emna Maalej, M. Carmo Carreiras, Bernard Refouvelet, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
alzheimer disease
kojic acid
multitarget small molecules
tacrine
Online Access:http://dx.doi.org/10.1080/14756366.2018.1538136

Internet

http://dx.doi.org/10.1080/14756366.2018.1538136

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