DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors

DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors

Summary: Alterations in the exonuclease domain of DNA polymerase ε cause ultramutated cancers. These cancers accumulate AGA>ATA transversions; however, their genomic features beyond the trinucleotide motifs are obscure. We analyze the extended DNA context of ultramutation using whole-exome sequen...

Full description

Bibliographic Details
Main Authors: Daria Ostroverkhova, Kathrin Tyryshkin, Annette K. Beach, Elizabeth A. Moore, Yosef Masoudi-Sobhanzadeh, Stephanie R. Barbari, Igor B. Rogozin, Konstantin V. Shaitan, Anna R. Panchenko, Polina V. Shcherbakova
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723016662

Internet

http://www.sciencedirect.com/science/article/pii/S2211124723016662

Similar Items