DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors

DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors

Summary: Alterations in the exonuclease domain of DNA polymerase ε cause ultramutated cancers. These cancers accumulate AGA>ATA transversions; however, their genomic features beyond the trinucleotide motifs are obscure. We analyze the extended DNA context of ultramutation using whole-exome sequen...

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Bibliographic Details
Main Authors:	Daria Ostroverkhova, Kathrin Tyryshkin, Annette K. Beach, Elizabeth A. Moore, Yosef Masoudi-Sobhanzadeh, Stephanie R. Barbari, Igor B. Rogozin, Konstantin V. Shaitan, Anna R. Panchenko, Polina V. Shcherbakova
Format:	Article
Language:	English
Published:	Elsevier 2024-01-01
Series:	Cell Reports
Subjects:	CP: Cancer
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124723016662

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