Empagliflozin Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats by Modulating Sesn2/AMPK/Nrf2 Signaling and Targeting Ferroptosis and Autophagy

Empagliflozin Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats by Modulating Sesn2/AMPK/Nrf2 Signaling and Targeting Ferroptosis and Autophagy

Pulmonary fibrosis (PF) is a life-threatening disorder that severely disrupts normal lung architecture and function, resulting in severe respiratory failure and death. It has no definite treatment. Empagliflozin (EMPA), a sodium-glucose cotransporter 2 (SGLT2) inhibitor, has protective potential in...

Full description

Bibliographic Details
Main Authors: Hemat El-Sayed El-Horany, Marwa Mohamed Atef, Muhammad Tarek Abdel Ghafar, Mohamed. H. Fouda, Nahla Anas Nasef, Islam Ibrahim Hegab, Duaa S. Helal, Walaa Elseady, Yasser Mostafa Hafez, Rasha Youssef Hagag, Monira Abdelmoaty Seleem, Mai Mahmoud Saleh, Doaa A. Radwan, Amal Ezzat Abd El-Lateef, Rania Nagi Abd-Ellatif
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
autophagy
bleomycin
empagliflozin
endoplasmic reticulum stress
ferroptosis
pulmonary fibrosis
Online Access:https://www.mdpi.com/1422-0067/24/11/9481

Internet

https://www.mdpi.com/1422-0067/24/11/9481

Similar Items