Small-Angle X-ray Scattering (SAXS) Used for the Identification of Nicomorphine Polymorphic Changes at the Early Stage to Avoid Varied Stability and Possible Side Effects

Small-Angle X-ray Scattering (SAXS) Used for the Identification of Nicomorphine Polymorphic Changes at the Early Stage to Avoid Varied Stability and Possible Side Effects

In this paper, we present the identification of polymorphisms at an early stage, identified by applying non-standard methods such as SAXS. We provide an analytical approach to polymorphism in the quality/purity of an active pharmaceutical ingredient (API), supplied to a generic company by two differ...

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Bibliographic Details
Main Authors: Nermina Malanovic, Giovanni Birarda, Simone Eder, Heidrun Gruber-Woelfler, Franz Reiter, Krunoslav Juraic, Aden Hodzic
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Pharmaceuticals
Subjects:
polymorphism
crystallinity
purity
solid-state drugs
powder
small-angle X-ray scattering
Online Access:https://www.mdpi.com/1424-8247/17/3/375

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https://www.mdpi.com/1424-8247/17/3/375

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