Rapid identification of anti-idiotypic mAbs with high affinity and diverse epitopes by rabbit single B-cell sorting-culture and cloning technology.

Rapid identification of anti-idiotypic mAbs with high affinity and diverse epitopes by rabbit single B-cell sorting-culture and cloning technology.

The proactive generation of anti-idiotypic antibodies (anti-IDs) against therapeutic antibodies with desirable properties is an important step in pre-clinical and clinical assay development supporting their bioanalytical programs. Here, we describe a robust platform to generate anti-IDs using rabbit...

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Bibliographic Details
Main Authors: WeiYu Lin, Wei-Ching Liang, Trung Nguy, Mauricio Maia, Tulika Tyagi, Cecilia Chiu, Kam Hon Hoi, Yongmei Chen, Yan Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0244158

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https://doi.org/10.1371/journal.pone.0244158

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