Functional antibodies against G-protein coupled receptors in Beagle dogs infected with two different strains of Trypanosoma cruzi

Functional antibodies against G-protein coupled receptors in Beagle dogs infected with two different strains of Trypanosoma cruzi

The interaction of the anti-beta1-adrenergic receptor autoantibodies (β1ARAb) and the anti-muscarinic M2 receptor autoantibodies (M2RAb) with cardiac neurotransmitter receptors were identified in human chronic Chagas cardiomyopathy (CCC) related to the ECG and dysautonomia disturbances. Dogs are con...

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Bibliographic Details
Main Authors: Gerd Wallukat, Fernando Antônio Botoni, Manoel Otávio da Costa Rocha, Vitória Louise, Johannes Müller, Andre Talvani
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
Trypanosoma cruzi
dog model
chagas disease
autoantibodies
g-protein coupled receptors
Cardiomyocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.926682/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.926682/full

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