Epigenetic, Metabolic, and Immune Crosstalk in Germinal-Center-Derived B-Cell Lymphomas: Unveiling New Vulnerabilities for Rational Combination Therapies

Epigenetic, Metabolic, and Immune Crosstalk in Germinal-Center-Derived B-Cell Lymphomas: Unveiling New Vulnerabilities for Rational Combination Therapies

B-cell non-Hodgkin lymphomas (B-NHLs) are highly heterogenous by genetic, phenotypic, and clinical appearance. Next-generation sequencing technologies and multi-dimensional data analyses have further refined the way these diseases can be more precisely classified by specific genomic, epigenomic, and...

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Bibliographic Details
Main Authors: Inna Serganova, Sanjukta Chakraborty, Samuel Yamshon, Yusuke Isshiki, Ryan Bucktrout, Ari Melnick, Wendy Béguelin, Roberta Zappasodi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
GCB-DLBCLs
epigenetics
metabolic intermediates
immune microenvironment
combination therapies
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.805195/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.805195/full

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