Nicorandil/ morphine crosstalk accounts for antinociception and hepatoprotection in hepatic fibrosis in rats: Distinct roles of opioid/cGMP and NO/KATP pathways

Nicorandil/ morphine crosstalk accounts for antinociception and hepatoprotection in hepatic fibrosis in rats: Distinct roles of opioid/cGMP and NO/KATP pathways

Previous report indicated that nicorandil potentiated morphine antinociception and attenuated hepatic injury in liver fibrotic rats. Herein, the underlying mechanisms of nicorandil/morphine interaction were investigated using pharmacological, biochemical, histopathological, and molecular docking stu...

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Bibliographic Details
Main Authors: Asser F. Bedair, Ahmed Wahid, Nesrine S. El-Mezayen, Amira F. El-Yazbi, Hadeel A. Khalil, Nayera W. Hassan, Elham A. Afify
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Nitric oxide
Opioidergic
KATP channels, liver fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223008594

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http://www.sciencedirect.com/science/article/pii/S0753332223008594

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