Rare Genetic Variants in Human <i>APC</i> Are Implicated in Mesiodens and Isolated Supernumerary Teeth

Rare Genetic Variants in Human <i>APC</i> Are Implicated in Mesiodens and Isolated Supernumerary Teeth

The activation of Wnt/β-catenin signalling is a prerequisite for odontogenesis. APC, a member of the AXIN-CK1-GSK3β-APC β-catenin destruction complex, functions to modulate Wnt/β-catenin signalling to establish regular teeth number and positions. APC loss-of-function mutations are associated with th...

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Bibliographic Details
Main Authors: Chomchanok Panyarat, Siriruk Nakornchai, Kanoknart Chintakanon, Niramol Leelaadisorn, Worrachet Intachai, Bjorn Olsen, Sissades Tongsima, Ploy Adisornkanj, Chumpol Ngamphiw, Timothy C. Cox, Piranit Kantaputra
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
Extra teeth
mesiodentes
Gardner syndrome
supernumerary tooth
WNT signaling
taurodontism
Online Access:https://www.mdpi.com/1422-0067/24/5/4255

Internet

https://www.mdpi.com/1422-0067/24/5/4255

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