Effect of Ions and Sequence Variants on the Antagonist Binding Properties of the Histamine H<sub>1</sub> Receptor

Effect of Ions and Sequence Variants on the Antagonist Binding Properties of the Histamine H<sub>1</sub> Receptor

The histamine H<sub>1</sub> receptor (H<sub>1</sub>R) is a G protein-coupled receptor (GPCR) and represents a main target in the treatment of allergic reactions as well as inflammatory reactions and depressions. Although the overall effect of antagonists on H<sub>1</...

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Bibliographic Details
Main Authors: Marcus Conrad, Christian A. Söldner, Heinrich Sticht
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
receptor-ligand interactions
G protein-coupled receptors (GPCRs)
molecular dynamics simulations
metadynamics
sodium binding
sodium pocket
Online Access:https://www.mdpi.com/1422-0067/23/3/1420

Internet

https://www.mdpi.com/1422-0067/23/3/1420

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