Posttransplant de novo DSA and NDSA affect GvHD, OS, and DFS after haplo-HSCT in patients without pre-existing HLA antibodies of hematological malignancies

Posttransplant de novo DSA and NDSA affect GvHD, OS, and DFS after haplo-HSCT in patients without pre-existing HLA antibodies of hematological malignancies

To examine the production time, type, and MFI of post-transplantation de novo HLA antibodies, and their effects on haplo-HSCT outcomes, we retrospectively included 116 patients who were negative for pre-existing HLA antibodies. In total, 322 serum samples from pre-transplantation to post-transplanta...

Full description

Bibliographic Details
Main Authors: Lan Wang, Kai Ji, Luyao Chen, Ying Li, Wenjuan Zhu, Xiaoni Yuan, Xiaojing Bao, Xiaojin Wu, Jun He
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
de novo human leukocyte antigen antibody (de novo HLA antibody)
donor-specific anti-HLA antibody (DSA)
acute graft-versus-host disease (aGvHD)
haploidentical hematopoietic stem cell transplantation (haplo-HSCT)
outcomes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1047200/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1047200/full

Similar Items