Humanized DRAGA mice immunized with Plasmodium falciparum sporozoites and chloroquine elicit protective pre-erythrocytic immunity

Humanized DRAGA mice immunized with Plasmodium falciparum sporozoites and chloroquine elicit protective pre-erythrocytic immunity

Abstract Background Human-immune-system humanized mouse models can bridge the gap between humans and conventional mice for testing human vaccines. The HLA-expressing humanized DRAGA (HLA-A2.HLA-DR4.Rag1KO.IL2RγcKO.NOD) mice reconstitute a functional human-immune-system and sustain the complete life...

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Bibliographic Details
Main Authors: Sai Majji, Wathsala Wijayalath, Soumya Shashikumar, Teodor D. Brumeanu, Sofia Casares
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Malaria Journal
Subjects:
Humanized DRAGA mice
Plasmodium falciparum
Malaria
Human T cells
Antibodies
Chloroquine
Online Access:http://link.springer.com/article/10.1186/s12936-018-2264-y

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http://link.springer.com/article/10.1186/s12936-018-2264-y

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